(6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester

Base Information

Chemical Name:(6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester
CAS No.:186503-36-6
Molecular Formula:C₂₄H₂₃NO₆S
Molecular Weight:453.516
Hs Code.:

Synonyms:(6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester

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Chemical Property of (6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester

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Technology Process of (6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester

There total 3 articles about (6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 98-88-4
benzoyl chloride

: 186503-35-5
(6R,7S)-7-Methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 186503-36-6
(6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; 1.) -70 deg C, 30 min, 2.) -70 deg C, 90 min;
DOI:10.1055/s-1998-1620

Reference yield:

: 22252-43-3,26395-99-3,70287-30-8,72059-35-9
3-deacetyloxy-7-aminocephalosporanic acid

: 186503-36-6
(6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₃SO₃H, NaNO₂ / 21 h / Ambient temperature

2: NaHCO₃, NaBr / dimethylformamide / 18 h / Ambient temperature

3: 75 percent / LDA / tetrahydrofuran / 1.) -70 deg C, 30 min, 2.) -70 deg C, 90 min

With methanesulfonic acid; sodium hydrogencarbonate; sodium bromide; lithium diisopropyl amide; sodium nitrite; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-1998-1620

Reference yield:

: 126621-86-1
7α-Methoxy-3-methyl-3-cephem-4-carboxylic acid

: 186503-36-6
(6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃, NaBr / dimethylformamide / 18 h / Ambient temperature

2: 75 percent / LDA / tetrahydrofuran / 1.) -70 deg C, 30 min, 2.) -70 deg C, 90 min

With sodium hydrogencarbonate; sodium bromide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-1998-1620