(R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Base Information

Chemical Name:(R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate
CAS No.:1280639-47-5
Molecular Formula:C₂₀H₂₃NO₅S
Molecular Weight:389.472
Hs Code.:

Synonyms:(R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

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Chemical Property of (R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

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Technology Process of (R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

There total 3 articles about (R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 543745-58-0
N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine

: 818-61-1,9051-31-4,26022-14-0
2-hydroxyethyl acrylate

: 1280639-47-5
(R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In toluene; at 120 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c0ob00835d

Reference yield:

: 65185-58-2
2-(2-bromophenyl)ethanamine

: 1280639-47-5
(R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / 120 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1039/c0ob00835d

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1280639-47-5
(R,S)-2-hydroxyethyl 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / 120 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1039/c0ob00835d