(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

Base Information

Chemical Name:(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine
CAS No.:142343-77-9
Molecular Formula:C₂₆H₂₇ClN₄O₂
Molecular Weight:462.979
Hs Code.:

Synonyms:(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

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Chemical Property of (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

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Technology Process of (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

There total 11 articles about (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: N⁴-((1R,2R,3S)-2,3-Bis-benzyloxymethyl-cyclobutyl)-6-chloro-5-(2,2-dimethoxy-ethyl)-pyrimidine-2,4-diamine

: 142343-77-9
(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

Guidance literature:: With hydrogenchloride;
DOI:10.1016/S0040-4039(00)74181-5

Reference yield:

: 100-39-0
benzyl bromide

: 142343-77-9
(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

Guidance literature:: Multi-step reaction with 10 steps

1: 1) NaH / 1) DMF

2: 100 percent / 0.5percent H₂SO₄ / acetonitrile

3: 81 percent / LS-Selectride / tetrahydrofuran / -78 °C

4: 48 percent / pyridine

5: 100 percent / KOH / methanol

6: 90 percent / pyridine

7: NaN₃ / dimethylformamide / 100 °C

8: BH₃*THF / tetrahydrofuran

9: Et₃N / butan-1-ol / 100 °C

10: 63 percent / 2 N HCl

With pyridine; hydrogenchloride; potassium hydroxide; sodium azide; borane-THF; sulfuric acid; sodium hydride; lithium tri-sec-butyl(hydrido)borate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;
DOI:10.1016/S0040-4039(00)74181-5

Reference yield:

: 126261-70-9,127696-11-1,132294-14-5,132294-22-5
(+/-)-trans-1,2-bis-(3,3-diethoxycyclobutylen)methanol

: 142343-77-9
(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

Guidance literature:: Multi-step reaction with 10 steps

1: 1) NaH / 1) DMF

2: 100 percent / 0.5percent H₂SO₄ / acetonitrile

3: 81 percent / LS-Selectride / tetrahydrofuran / -78 °C

4: 48 percent / pyridine

5: 100 percent / KOH / methanol

6: 90 percent / pyridine

7: NaN₃ / dimethylformamide / 100 °C

8: BH₃*THF / tetrahydrofuran

9: Et₃N / butan-1-ol / 100 °C

10: 63 percent / 2 N HCl

With pyridine; hydrogenchloride; potassium hydroxide; sodium azide; borane-THF; sulfuric acid; sodium hydride; lithium tri-sec-butyl(hydrido)borate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;
DOI:10.1016/S0040-4039(00)74181-5