Technology Process of N-benzyloxycarbonyl-cis-2(R)-(acetoxymethyl)-6(S)-(hydroxymethyl)piperidine
There total 11 articles about N-benzyloxycarbonyl-cis-2(R)-(acetoxymethyl)-6(S)-(hydroxymethyl)piperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2,2-dimethoxypropane, HCl / 1.) reflux, 4 h, 2.) room temperature, overnight
2: 17.8 g / hydrogen / palladium on carbon / H2O / 15 h / 775.7 Torr / Ambient temperature
3: 95 percent / diisopropylethylamine / tetrahydrofuran / 4 h / Ambient temperature
4: 84 percent / LiBH4 / tetrahydrofuran / 5 h
5: 97 percent / pyridine, 4-dimethylaminopyridine / 0.5 h / Heating
6: 82 percent / potassium dihydrogen phosphate, sodium hydroxide / acetonitrile; H2O / 108 h / Ambient temperature; pH 7.0, Aspergillus niger lipase presence, other biologically active material: wheat germ lipase
With
pyridine; hydrogenchloride; dmap; sodium hydroxide; potassium dihydrogenphosphate; lithium borohydride; hydrogen; N-ethyl-N,N-diisopropylamine; 2,2-dimethoxy-propane;
palladium on activated charcoal;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo9519569
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2,2-dimethoxypropane, HCl / 1.) reflux, 4 h, 2.) room temperature, overnight
2: hydrogen / rhodium on alumina / H2O / 15 h / 775.7 Torr / Ambient temperature
3: 95 percent / diisopropylethylamine / tetrahydrofuran / 4 h / Ambient temperature
4: 84 percent / LiBH4 / tetrahydrofuran / 5 h
5: 97 percent / pyridine, 4-dimethylaminopyridine / 0.5 h / Heating
6: 82 percent / potassium dihydrogen phosphate, sodium hydroxide / acetonitrile; H2O / 108 h / Ambient temperature; pH 7.0, Aspergillus niger lipase presence, other biologically active material: wheat germ lipase
With
pyridine; hydrogenchloride; dmap; sodium hydroxide; potassium dihydrogenphosphate; lithium borohydride; hydrogen; N-ethyl-N,N-diisopropylamine; 2,2-dimethoxy-propane;
Rh/Al2O3;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo9519569
