(+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate

Base Information

• Chemical Name: (+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate
• CAS No.: 675124-83-1
• Molecular Formula: C₁₇H₁₉FN₂O₃S
• Molecular Weight: 350.414

Synonyms:(+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate

Chemical Property of (+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate

Chemical Property:

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Technology Process of (+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate

There total 1 articles about (+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl [(2S,4S,5R,SS)-5-(p-fluorophenyl)-2-phenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate (596823-40-4) → (+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate (675124-83-1)

Guidance literature:

With phosphoric acid; In tetrahydrofuran; water; at 0 - 20 ℃; for 6h;

DOI:10.1021/jo035613j

Reference yield: 90.0%

chloroacetyl chloride (79-04-9) + (+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate (675124-83-1) → (+)-methyl (2S,3R,SS)-2-chloroacetylamino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)propanoate

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 0 - 20 ℃; for 2.25h;

DOI:10.1021/jo052077h

Reference yield: 78.0%

Benzophenone imine (1013-88-3) + (+)-methyl [(2S,3R,Ss)-2-amino-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate (675124-83-1) → (-)-methyl [(2S,3R,Ss)-2-(benzhydrylidenamino)-3-(p-fluorophenyl)-3-(p-tolylsulfinylamino)]propanoate

Guidance literature:

In dichloromethane; at 20 ℃; for 25h;

DOI:10.1021/jo035613j

upstream raw materials:

methyl [(2S,4S,5R,S_S)-5-(p-fluorophenyl)-2-phenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate

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