methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate

Base Information

• Chemical Name: methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate
• CAS No.: 1407998-17-7
• Molecular Formula: C₁₉H₁₆FNO₃
• Molecular Weight: 325.339
• Mol file: 1407998-17-7.mol

Synonyms:methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate

Chemical Property of methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate

Chemical Property:

Purity/Quality:

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Technology Process of methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate

There total 1 articles about methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3'-Dimethoxycarbonylpropanoic anhydride (52944-79-3) + 1-(4-fluorophenyl)-2-phenylethanone (347-84-2) → methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate (1407998-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; hydroxylamine hydrochloride / methanol

2: boron trifluoride diethyl etherate; [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / Reflux

With [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium acetate; In methanol; 1,2-dichloro-ethane;

DOI:10.1021/jo302073e

Reference yield: 93.0%

methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate (1407998-17-7) → 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoic acid (1407998-19-9)

Guidance literature:

methyl 3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoate; With sodium hydroxide; In methanol; water; at 50 ℃;

With hydrogenchloride; In methanol; water; at 20 ℃;

DOI:10.1021/jo302073e

upstream raw materials:

3,3'-Dimethoxycarbonylpropanoic anhydride

1-(4-fluorophenyl)-2-phenylethanone

Downstream raw materials:

3-(4-(4-fluorophenyl)-5-phenyloxazol-2-yl)propanoic acid