Welcome to LookChem.com Sign In|Join Free

CAS

  • or

347-84-2

Post Buying Request

347-84-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

347-84-2 Usage

Description

4'-FLUORO-2-PHENYLACETOPHENONE, also known as 1-(4-Fluorophenyl)-2-phenyl-ethanone, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by the presence of a fluorophenyl and phenyl group attached to an ethanone moiety, which contributes to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
4'-FLUORO-2-PHENYLACETOPHENONE is used as a chemical intermediate for the preparation of 2,3-diarylpyrazines and quinoxalines, which are selective COX-2 inhibitors. These inhibitors play a crucial role in the development of anti-inflammatory and analgesic drugs, as they help reduce inflammation and pain by targeting the specific enzyme responsible for prostaglandin synthesis.
In the synthesis of these compounds, 4'-FLUORO-2-PHENYLACETOPHENONE serves as a building block, providing the necessary structural elements for the formation of the desired molecules. Its presence in the final product contributes to the overall effectiveness and selectivity of the COX-2 inhibitors, making it an essential component in the development of new and improved pharmaceuticals for the treatment of various inflammatory and pain-related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 347-84-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 347-84:
(5*3)+(4*4)+(3*7)+(2*8)+(1*4)=72
72 % 10 = 2
So 347-84-2 is a valid CAS Registry Number.

347-84-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-fluorophenyl)-2-phenylethanone

1.2 Other means of identification

Product number -
Other names Benzyl 4-fluorophenyl ketone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:347-84-2 SDS

347-84-2Relevant articles and documents

Electrochemical oxidation-induced benzyl C–H carbonylation for the synthesis of aromatic α-diketones

Tan, Yu-Fang,Chen, Yuan,Li, Rui-Xue,Guan, Zhi,He, Yan-Hong

supporting information, (2021/12/21)

Electrochemical oxidation-induced direct carbonylation of benzyl C–H bond for the synthesis of aromatic α-diketones is described. In this process, tetrabutylammonium iodide (nBu4NI) not only acts as an electrolyte, but its iodine anion is oxidized to an iodine radical at the anode, acting as a hydrogen atom transfer agent. The iodine radical extracts the benzyl hydrogen atom and causes the carbonylation of the benzyl position, where O2 in the air is used as an oxygen source.

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Kandasamy, Jeyakumar,Lee, Yong Rok,Singh, Adesh Kumar,Venkatesh, Rapelly

, p. 7832 - 7837 (2021/09/28)

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.

Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System

Dai, Ziteng,Gu, Yuanyun,Li, Jie,Mao, Jianyou,Walsh, Patrick J.,Wang, Yan-En,Xiong, Dan,Yuan, Yaqi,Zhang, Zhen

supporting information, (2022/01/14)

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple methyl benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alcohol products. This finding greatly increases the practicality and impact of this chemistry. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 347-84-2