(S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:(S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283146-49-5
Molecular Formula:C₂₀H₁₅ClF₆N₂O
Molecular Weight:448.795
Hs Code.:

Synonyms:(S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of (S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Chemical Property:

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Technology Process of (S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

There total 2 articles about (S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1283146-31-5
2-((2S,4S)-1-(4-hydroxyphenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: 78068-85-6
3-chloro-4-fluoro benzotrifluoride

: 1283146-49-5
(S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: (S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 2h;

Reference yield:

: 1283146-30-4
2-((2S,4S)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: 1283146-49-5
(S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: (S)-2-(1-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; acetic acid / palladium on activated charcoal / ethyl acetate / 144 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C

With hydrogen; caesium carbonate; acetic acid; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;