hydrochloride salt of 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoic acid

Base Information

• Chemical Name: hydrochloride salt of 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoic acid
• CAS No.: 1221962-00-0
• Molecular Formula: C₂₃H₁₉ClN₂O₃*ClH
• Molecular Weight: 443.329
• Mol file: 1221962-00-0.mol

Synonyms:hydrochloride salt of 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoic acid

Chemical Property of hydrochloride salt of 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydrochloride salt of 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoic acid

There total 6 articles about hydrochloride salt of 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoate (1221962-03-3) → 3-(4-chlorophenyl)-4-(6-phenoxy-2-benzimidazolyl)butanoic acid hydrochloride (1221962-00-0)

Guidance literature:

With hydrogenchloride; acetic acid; In water; at 100 ℃; for 1h;

Reference yield:

methyl 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoate (1221962-03-3) → hydrochloride salt of 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoic acid (1221962-00-0)

Guidance literature:

With hydrogenchloride; water; acetic acid; at 100 ℃; for 1h;

Reference yield:

3-(4-chlorophenyl)pentane-1,5-dioic acid (35271-74-0) → 3-(4-chlorophenyl)-4-(6-phenoxy-2-benzimidazolyl)butanoic acid hydrochloride (1221962-00-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetyl chloride / 2 h / Reflux

2.1: triethylamine / 1,4-dioxane / 2.5 h / 20 - 40 °C

2.2: Cooling with ice

3.1: nitric acid; acetic acid / 0.5 h / 20 - 30 °C

3.2: Cooling with ice

4.1: hydrogenchloride; iron / water; methanol / 21 h / Reflux

4.2: 20 °C

5.1: hydrogenchloride; acetic acid / water / 1 h / 100 °C

With hydrogenchloride; nitric acid; iron; acetic acid; triethylamine; acetyl chloride; In 1,4-dioxane; methanol; water;

upstream raw materials:

methyl 3-(4-chlorophenyl)-4-(5-phenoxy-2-benzimidazolyl)butanoate

3-(4-chlorophenyl)glutaric anhydride

3-(4-chlorophenyl)pentane-1,5-dioic acid

N-(4-phenoxyphenyl)-3-(4-chlorophenyl)-glutaramic acid

Refernces

• 1、 -. "ALLOSTERIC PROTEIN KINASE MODULATORS". Page/Page column 63. . Retrieved 2010/04/30.