(S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide

Base Information

• Chemical Name: (S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide
• CAS No.: 1223578-72-0
• Molecular Formula: C₁₂H₁₆F₃NO₂S
• Molecular Weight: 295.326

Synonyms:(S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide

Chemical Property of (S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide

Chemical Property:

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Technology Process of (S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide

There total 2 articles about (S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

(S)-N-[(E)-3-methoxybenzylidene]-2-propanesulfinamide (1006592-88-6) + (trifluoromethyl)trimethylsilane (81290-20-2) → (S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide (1223578-72-0)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; In toluene; at -50 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.200901158

Reference yield: 86.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + (S)-(E)-N-(benzylidene)isopropanesulfinamide (850924-08-2) → (S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide (1223578-72-0)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; In toluene; at -50 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.200901158

Reference yield: 69.0%

(S(S),R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide (1223578-72-0) → (R)-2,2,2-trifluoro-1-(3-methoxyphenyl)ethylamine (1213162-90-3,856758-72-0)

Guidance literature:

With trifluoroacetic acid; In methanol; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200901158

upstream raw materials:

(S)-N-[(E)-3-methoxybenzylidene]-2-propanesulfinamide

(trifluoromethyl)trimethylsilane

(S)-(E)-N-(benzylidene)isopropanesulfinamide

Downstream raw materials:

(R)-2,2,2-trifluoro-1-(3-methoxyphenyl)ethylamine

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