4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide
• CAS No.: 374632-73-2
• Molecular Formula: C₁₉H₂₀N₄O₃S
• Molecular Weight: 384.459

Synonyms:4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide

Chemical Property of 4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide

Chemical Property:

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Technology Process of 4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide

There total 2 articles about 4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

1-phenylpyrazol-5-amine (826-85-7) + sulfonyl chloride (35450-53-4) → 4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide (374632-73-2)

Guidance literature:

With pyridine; at 95 ℃; for 2h;

DOI:10.1021/jm010861y

Reference yield:

methyl-N-(benzyl-methyl)-formamide (877-95-2) → 4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide (374632-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / chlorosulfonic acid / 3 h / 50 - 70 °C

2: 26 percent / pyridine / 2 h / 95 °C

With pyridine; chlorosulfonic acid;

DOI:10.1021/jm010861y

Reference yield: 86.0%

3-bromopropyl benzoate (6065-69-6) + 4-[2-(acetylamino)ethyl]-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide (374632-73-2) → benzoic acid 3-[[4-(2-acetylamino-ethyl)-benzenesulfonyl]-(2-phenyl-2H-pyrazol-3-yl)-amino]-propyl ester (693789-89-8)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1021/jm010861y

upstream raw materials:

1-phenylpyrazol-5-amine

sulfonyl chloride

methyl-N-(benzyl-methyl)-formamide

Downstream raw materials:

benzoic acid 3-[[4-(2-acetylamino-ethyl)-benzenesulfonyl]-(2-phenyl-2H-pyrazol-3-yl)-amino]-propyl ester

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