Technology Process of N-cyclopropylmethyl-N-[7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-(methoxymethyl)pyrazolo[1,5-a]pyridin-3-yl]amine
There total 15 articles about N-cyclopropylmethyl-N-[7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-(methoxymethyl)pyrazolo[1,5-a]pyridin-3-yl]amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl N-cyclopropylmethyl-N-[7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-(methoxymethyl)pyrazolo[1,5-a]pyridin-3-yl]carbamate;
With
hydrogenchloride;
In
ethyl acetate;
at 40 ℃;
for 0.5h;
With
sodium hydroxide;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: copper(l) iodide; diethylamine / bis-triphenylphosphine-palladium(II) chloride / 1 h / 40 °C
2.1: dichloromethane / 0.5 h / 0 °C
3.1: sodium methylate / methanol / 0.33 h / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.2: 0.5 h / -78 °C
4.3: -78 - 20 °C
5.1: nitronium tetrafluoborate / acetonitrile / 0 °C
6.1: acetic acid; zinc / ethanol; water
7.1: triethylamine / dichloromethane / 0 - 20 °C
8.1: barium dihydroxide / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 2 h / 80 °C
9.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 40 °C
10.1: hydrogenchloride / ethyl acetate / 0.5 h / 40 °C
With
hydrogenchloride; barium dihydroxide; copper(l) iodide; n-butyllithium; nitronium tetrafluoborate; sodium methylate; sodium hydride; acetic acid; diethylamine; triethylamine; zinc;
bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: barium dihydroxide / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 2 h / 80 °C
2: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 40 °C
3: hydrogenchloride / ethyl acetate / 0.5 h / 40 °C
With
hydrogenchloride; barium dihydroxide; sodium hydride;
tetrakis(triphenylphosphine) palladium(0);
In
DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; water; ethyl acetate;
![tert-butyl N-cyclopropylmethyl-N-[7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-(methoxymethyl)pyrazolo[1,5-a]pyridin-3-yl]carbamate](/Databaselist/images/loading.webp)
