5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

Base Information

Chemical Name:5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester
CAS No.:511295-15-1
Molecular Formula:C₃₆H₃₆Cl₂O₈
Molecular Weight:667.583
Hs Code.:

Synonyms:5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

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Chemical Property of 5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

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Technology Process of 5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

There total 21 articles about 5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5'-Chloro-2'-[(E)-2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-vinyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

: 511295-15-1
5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; for 24h; under 2625.21 Torr;
DOI:10.1055/s-2002-35629

Reference yield:

: 621-59-0
isovanillin

: 511295-15-1
5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / 1 h / Heating

2: 79 percent / N,N'-dichloropiperazine / aq. H₂SO₄ / 1 h / 20 °C

3: 95 percent / aq. NaOH / 2 h / Heating

4: 96 percent / p-TosOH / toluene / 24 h / Heating

5: 68 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

6: 81 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / 24 h / Heating

7: 68 percent / K₂CO₃; 18-crown-6 / CH₂Cl₂ / 24 h / Heating

8: 86 percent / H₂; Et₃N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr

With pyridine; N,N'-dichloropiperazine; sodium hydroxide; 18-crown-6 ether; hydrogen; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; sulfuric acid; ethyl acetate; toluene; 6: Suzuki reaction / 7: Wittig reaction;
DOI:10.1055/s-2002-35629

Reference yield:

: 2420-16-8
4-hydroxy-3-chlorobenzaldehyde

: 511295-15-1
5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / Br₂ / acetic acid / 24 h / 80 °C

2: 80 percent / NaOH / 0.17 h / 100 °C

3: 77 percent / p-TosOH / toluene / 24 h / Heating

4: 84 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 80 °C

5: 68 percent / K₂CO₃; 18-crown-6 / CH₂Cl₂ / 24 h / Heating

6: 86 percent / H₂; Et₃N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr

With sodium hydroxide; potassium phosphate; 18-crown-6 ether; hydrogen; bromine; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; 4: Suzuki reaction / 5: Wittig reaction;
DOI:10.1055/s-2002-35629