(3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl

Base Information

Chemical Name:(3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl
CAS No.:374602-79-6
Molecular Formula:C₁₃H₂₂N₂O₃*ClH
Molecular Weight:290.79
Hs Code.:

Synonyms:(3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl

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Chemical Property of (3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl

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Technology Process of (3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl

There total 2 articles about (3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 270902-69-7
(3S,6R)-3-(tert-butoxycarbonyl)aminohexahydro-6-(cyclohexanecarbonyl)-oxy-2H-azepin-2-one

: 374602-79-6
(3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 15 - 23 ℃; for 6h; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/op0341162

Reference yield:

: 2219-28-5
(R)-5-hydroxy-L-lysine dihydrochloride hydrate

: 374602-79-6
(3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl

Guidance literature:: Multi-step reaction with 5 steps

1: chloro-trimethyl-silane / 3 h / 63 °C / Inert atmosphere

2: triethylamine / methanol / 3 h / 50 °C / Inert atmosphere

3: methanol / 1 h / 25 °C / Inert atmosphere

4: dmap / ethyl acetate / 3 h / 50 °C / Inert atmosphere

5: hydrogenchloride / ethyl acetate / 6 h / 15 - 23 °C / Inert atmosphere

With hydrogenchloride; dmap; chloro-trimethyl-silane; triethylamine; In methanol; ethyl acetate;
DOI:10.1021/op0341162

Reference yield: 88.0%

: 374602-79-6
(3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl

: 270902-67-5
8,8-dimethyl-2-O-methyl-3,5-O-(1-methylethylidene)-6,7,8,9-tetradeoxy-D-gluo-6-nonenonic acid (6E)-γ-lactone

: 270902-71-1
(2R,3R,4S,5R,6E)-3,5-(methylethylidene)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-N-[(3S,6R)-hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl]non-6-enamide

Guidance literature:: With sodium 2-ethylhexanoic acid; In tetrahydrofuran; at 23 ℃; for 20h; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/op0341162