2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol

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Chemical Name:2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol
CAS No.:936642-18-1
Molecular Formula:C₂₃H₃₂N₄O₆S
Molecular Weight:492.596
Hs Code.:

Synonyms:2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol

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Chemical Property of 2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol

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Technology Process of 2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol

There total 27 articles about 2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 936642-17-0
C₁₄H₂₄O₄

: 717124-35-1
5-(but-3-ent-1-sulfonyl)-1-phenyl-1H-tetrazole

: 936642-18-1
2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 45 ℃; for 22h;
DOI:10.1021/ol0701013

Reference yield: 76.0%

: C₂₉H₄₆N₄O₄SSi

: 936642-18-1
2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol

Guidance literature:: C₂₉H₄₆N₄O₄SSi; With ammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In tetrahydrofuran; ethanol; water; at 0 - 23 ℃; for 14h; pH=7.5; Inert atmosphere; aq. phosphate buffer;

With pyridine hydrofluoride; In tetrahydrofuran; at 23 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo202631e

Reference yield:

: 936642-16-9
((4aS,5S,7S,8aR)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2,2,4a-trimethylhexahydropyrano[4,3-d][1,3]dioxin-7-yl)-methanol

: 936642-18-1
2-((4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-((E)-4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)but-1-en-1-yl)hexahydropyrano[4,3-d]-[1,3]dioxin-5-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

2.1: lithium hexamethyldisilazide / tetrahydrofuran / 0.5 h / 0 °C

2.2: 96 mg / tetrahydrofuran / 20 °C

3.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

4.1: 81 percent / 2nd generation Grubbs' catalyst / CH₂Cl₂ / 22 h / 45 °C

With tetrabutyl ammonium fluoride; Dess-Martin periodane; lithium hexamethyldisilazane; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane; 1.1: Dess-Martin oxidation / 2.2: Wittig reaction;
DOI:10.1021/ol0701013