4-TRIFLUOROMETHYLSULFANYL-BIPHENYL

Base Information

• Chemical Name: 4-TRIFLUOROMETHYLSULFANYL-BIPHENYL
• CAS No.: 177551-63-2
• Molecular Formula: C13H9 F3 S
• Molecular Weight: 254.276
• Hs Code.: 2930909090
• Mol file: 177551-63-2.mol

Synonyms:4-(Trifluoromethylthio)biphenyl

Chemical Property of 4-TRIFLUOROMETHYLSULFANYL-BIPHENYL

Chemical Property:

• PSA: 0.00000
• LogP: 4.37240

Purity/Quality:

98%min ^*data from raw suppliers

[1,1'-Biphenyl]-4-yl(trifluoromethyl)sulfane 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TRIFLUOROMETHYLSULFANYL-BIPHENYL

There total 66 articles about 4-TRIFLUOROMETHYLSULFANYL-BIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-iodo-biphenyl (1591-31-7) + tetramethylammonium trifluoromethanethiolate → [1,1′-biphenyl]-4-yl(trifluoromethyl)sulfane (177551-63-2)

Guidance literature:

With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In toluene; at 80 ℃;

DOI:10.1002/anie.201501617

Reference yield: 96.0%

4-bromo-1,1'-biphenyl (92-66-0) + tetramethylammonium trifluoromethanethiolate → [1,1′-biphenyl]-4-yl(trifluoromethyl)sulfane (177551-63-2)

Guidance literature:

With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In toluene; at 80 ℃;

DOI:10.1002/anie.201501617

Reference yield: 91.0%

S-(trifluoromethyl)(S)-2-(6-methoxynaphthalen-2-yl)propanethioate → [1,1′-biphenyl]-4-yl(trifluoromethyl)sulfane (177551-63-2)

Guidance literature:

With bis(tri-ortho-tolylphosphine)palladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; In toluene; at 130 ℃; for 20h; Inert atmosphere;

DOI:10.1039/c9sc03396c

upstream raw materials:

biphenyl

trifluoromethylsulfonic anhydride

potassium triflinate

4-bromo-1,1'-biphenyl

Downstream raw materials:

rhodium hydrido (PEt₃)3 complex

Refernces

• 1、 Mao, Runze,Bera, Srikrishna,Cheseaux, Alexis,Hu, Xile. "Deoxygenative trifluoromethylthiolation of carboxylic acids". . p. 9555 - 9559. Retrieved 2019.
• 2、 Meng, Depei,Lyu, Yichong,Ni, Chuanfa,Zhou, Min,Li, Yang,Hu, Jinbo. "S-(Trifluoromethyl)Benzothioate (TFBT): A KF-Based Reagent for Nucleophilic Trifluoromethylthiolation". supporting information. . Retrieved 2022/02/17.
• 3、 Zheng, Changge,Jiang, Chao,Huang, Shuai,Zhao, Kui,Fu, Yingying,Ma, Mingyu,Hong, Jianquan. "Transition-Metal-Free Synthesis of Aryl Trifluoromethyl Thioethers through Indirect Trifluoromethylthiolation of Sodium Arylsulfinate with TMSCF3". supporting information. p. 6982 - 6986. Retrieved 2021/09/08.