5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

Base Information

Chemical Name:5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine
CAS No.:1418299-54-3
Molecular Formula:C₂₂H₁₇N₃O
Molecular Weight:339.396
Hs Code.:

Synonyms:5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

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Chemical Property of 5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

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Technology Process of 5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

There total 3 articles about 5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1016672-39-1
5-bromo-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

: 768-60-5
4-methoxyphenylacetylen

: 1418299-54-3
5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 120 ℃; Inert atmosphere; Sealed tube;
DOI:10.1016/j.tet.2012.11.026

Reference yield:

: 1131-18-6
1-Phenyl-3-methyl-5-aminopyrazole

: 1418299-54-3
5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr / Inert atmosphere

3: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 12 h / 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; chloro-trimethyl-silane; tert.-butylnitrite; palladium 10% on activated carbon; hydrogen; triethylamine; copper(ll) bromide; In methanol; N,N-dimethyl-formamide; acetonitrile; 4: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2012.11.026

Reference yield:

: 1181669-30-6
3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-amine

: 1418299-54-3
5-(2-(4-methoxyphenyl)ethynyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 12 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; triethylamine; copper(ll) bromide; In N,N-dimethyl-formamide; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2012.11.026