2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

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Chemical Name:2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine
CAS No.:1332875-70-3
Molecular Formula:C₂₂H₂₂F₃N₅O
Molecular Weight:429.445
Hs Code.:

Synonyms:2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

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Chemical Property of 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

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Technology Process of 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

There total 8 articles about 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₄F₃N₅O₅

: 1332875-70-3
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

: 1332875-68-9
2-(5-tert-butyl-4-methoxy-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: C₂₃H₂₄F₃N₅O₅; With iron; acetic acid; at 100 ℃; for 1h;

With lithium hydroxide; In water; ethyl acetate;

Reference yield:

: 13395-36-3
ethyl trimethylacetopyruvate

: 1332875-70-3
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-[(trifluoroacetoxy)iodo]benzene / 0.05 h / 20 °C

1.2: 20 °C

1.3: 8 h / 80 °C

2.1: sodium hydroxide; methanol / 18 h / 20 °C

2.2: pH ~ 2

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

4.2: 0 °C

5.1: iron / acetic acid / 1 h / 100 °C

With methanol; oxalyl dichloride; iron; sodium hydride; bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2897-43-0
2,6-dichloro-3-nitropyridin-4-amine

: 1332875-70-3
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 2 h / 100 °C / Sealed tube

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 15 h / 80 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

3.2: 0 °C

4.1: iron / acetic acid / 1 h / 100 °C

With iron; sodium hydride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; mineral oil; 2.1: Suzuki Coupling;