2897-43-0Relevant articles and documents
Efficient synthesis of 4-amino-2,6-dichloropyridine and its derivatives
Ma, Congming,Liu, Zuliang,Yao, Qizheng
, p. 251 - 254 (2016/10/24)
A facile synthetic route to an important intermediate 4-amino-2,6-dichloropyridine was developed. Oxidation of 2,6-dichloropyridine as a starting material gave pyridine N-oxide derivative which was subjected to nitration followed by reduction. Subsequent nitration of the product and nucleophilic displacement reaction were carried out to afford fully substituted energetic pyridine derivatives. Most of the synthetic reactions proceeded under mild conditions.