1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

Base Information

Chemical Name:1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid
CAS No.:1020173-41-4
Molecular Formula:C₂₅H₂₇N₃O₄
Molecular Weight:433.507
Hs Code.:

Synonyms:1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

Suppliers and Price of 1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Matrix Scientific
1-(2-((Benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid 95%
10g
$ 13320.00

Matrix Scientific
1-(2-((Benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid 95%
5g
$ 8880.00

Total 1 raw suppliers

Chemical Property of 1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

1-(2-((Benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid 95% ^*data from reagent suppliers

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Technology Process of 1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

There total 3 articles about 1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1020173-40-3
benzyl 6-(3-tert-butyl-5-(ethoxycarbonyl)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1020173-41-4
1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: benzyl 6-(3-tert-butyl-5-(ethoxycarbonyl)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; ethanol; at 22 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 1020174-05-3
benzyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1020173-41-4
1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium periodate / water; tetrahydrofuran / 0.5 h / 25 °C

1.2: 2.5 h

2.1: pyridine; copper diacetate / dichloromethane / 40 h / 25 °C / Molecular sieve

3.1: lithium hydroxide monohydrate; water / ethanol; tetrahydrofuran / 3 h / 22 °C

3.2: pH 2 - 3

With pyridine; sodium periodate; lithium hydroxide monohydrate; water; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 1020173-39-0
(2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)boronic acid

: 1020173-41-4
1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; copper diacetate / dichloromethane / 40 h / 25 °C / Molecular sieve

2.1: lithium hydroxide monohydrate; water / ethanol; tetrahydrofuran / 3 h / 22 °C

2.2: pH 2 - 3

With pyridine; lithium hydroxide monohydrate; water; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane;