benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1020173-78-7
Molecular Formula:C₂₇H₂₉Cl₃N₄O₄
Molecular Weight:579.911
Hs Code.:

Synonyms:benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 4 articles about benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1020173-41-4
1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

: 115-20-8
1,1,1-trichloroethanol

: 1020173-78-7
benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: 1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 20 ℃; for 0.5h;

1,1,1-trichloroethanol; In 1,4-dioxane; at 100 ℃; for 4h;

Reference yield:

: 1020173-40-3
benzyl 6-(3-tert-butyl-5-(ethoxycarbonyl)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1020173-78-7
benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate; water / ethanol; tetrahydrofuran / 3 h / 22 °C

1.2: pH 2 - 3

2.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 4 h / 100 °C

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 1020174-05-3
benzyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1020173-78-7
benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate / water; tetrahydrofuran / 0.5 h / 25 °C

1.2: 2.5 h

2.1: pyridine; copper diacetate / dichloromethane / 40 h / 25 °C / Molecular sieve

3.1: lithium hydroxide monohydrate; water / ethanol; tetrahydrofuran / 3 h / 22 °C

3.2: pH 2 - 3

4.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 4 h / 100 °C

With pyridine; sodium periodate; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; copper diacetate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;