[4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride

Base Information

Chemical Name:[4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride
CAS No.:1091681-80-9
Molecular Formula:C₂₀H₂₃FN₂O₂*ClH
Molecular Weight:378.874
Hs Code.:

Synonyms:[4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride

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Chemical Property of [4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride

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Technology Process of [4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride

There total 8 articles about [4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1091681-78-5
4-benzyloxycarbonylamino-4-(4-fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1091681-80-9
[4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;

Reference yield:

: 917834-41-4
tert-butyl 4-(benzyloxycarbonylamino)-4-(hydroxymethyl)piperidine-1-carboxylate

: 1091681-80-9
[4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tetrachloromethane; triphenylphosphine / benzene / 4 h / Heating / reflux

2: palladium diacetate; triphenylphosphine / tetrahydrofuran / 20 h / 0 - 20 °C

3: hydrogenchloride / ethyl acetate

With hydrogenchloride; tetrachloromethane; triphenylphosphine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; ethyl acetate; benzene;

Reference yield:

: 392331-67-8
1-(tert-butyl) 4-methyl 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)piperidine-1,4-dicarboxylate

: 1091681-80-9
[4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran / 20 h / 20 °C

2: tetrachloromethane; triphenylphosphine / benzene / 4 h / Heating / reflux

3: palladium diacetate; triphenylphosphine / tetrahydrofuran / 20 h / 0 - 20 °C

4: hydrogenchloride / ethyl acetate

With hydrogenchloride; tetrachloromethane; lithium borohydride; triphenylphosphine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; ethyl acetate; benzene;