N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine

Base Information

Chemical Name:N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine
CAS No.:864277-08-7
Molecular Formula:C₂₈H₃₄N₄O₄S₂
Molecular Weight:554.734
Hs Code.:

Synonyms:N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine

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Chemical Property of N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine

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Technology Process of N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine

There total 5 articles about N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 864277-04-3
1-(5-ethoxycarbonylthiazol-2-yl)-4-(4-iodophenylsulfonyl)piperazine

: 859833-21-9
1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine

: 864277-08-7
N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; water; at 70 ℃; for 10h;
DOI:10.1002/ejoc.201901729

Reference yield:

: 59507-40-3
1-(3-bromobenzyl)piperidine

: 864277-04-3
1-(5-ethoxycarbonylthiazol-2-yl)-4-(4-iodophenylsulfonyl)piperazine

: 864277-08-7
N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine

Guidance literature:: 1-(3-bromobenzyl)piperidine; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Flow reactor;

With Trimethyl borate; In tetrahydrofuran; hexane; at 0 ℃; Flow reactor;

1-(5-ethoxycarbonylthiazol-2-yl)-4-(4-iodophenylsulfonyl)piperazine; With tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 50 ℃; Flow reactor;
DOI:10.1002/ejoc.201901729

Reference yield:

: 41731-83-3
ethyl 2-bromo-1,3-thiazole-5-carboxylate

: 864277-08-7
N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 13 h / 90 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: 12 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Flow reactor

3.2: 0 °C / Flow reactor

3.3: 50 °C / Flow reactor

With n-butyllithium; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 3.3: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201901729