41731-83-3

Usage

Uses

Ethyl 2-bromothiazole-5-carboxylate is used in medicine, pharmaceutical intermediate

InChI:InChI=1/C6H6BrNO2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3

Upstream product

• 32955-21-8 2-amino-thiazole-5-carboxylic acid ethyl ester 
• 12775-96-1 copper 
• 3034-53-5 2-bromo-1,3-thiazole 
• 623-49-4 ethyl cyanoformate 

Downstream Products

• 54045-76-0 2-bromo-thiazole-5-carboxylic acid 
• 591777-89-8 ethyl 2-anilino-1,3-thiazole-5-carboxylate 
• 867315-08-0 2-(3-chloro-phenoxy)-thiazol-5-carboxylic acid ethyl ester 
• 939803-89-1 2-[3-((1R,2S,3R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-2-{4-[1-(tert-butyl-dimethyl-silanyloxy)-hexyl]-phenyl}-5-chloro-cyclopentyl)-propyl]-thiazole-5-carboxylic acid ethyl ester 
• 864277-03-2 2-piperazin-1-yl-thiazol-5-carboxylic acid ethyl ester 
• 56355-60-3 ethyl 2-phenylsulphanylthiazole-5-carboxylate 
• 400715-48-2 ethyl 2-(2fluorophenyl)thiazole-5-carboxylate 
• 56355-59-0 Ethyl 2-(4-chlorophenoxy)thiazole-5-carboxylate 
• 937729-02-7 Ethyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)-1,3-thiazole-5-carboxylate 
• 687636-93-7 (2-bromothiazole-5-yl)methanol 
• 216867-46-8 2-(pyridin-4-yl)thiazole-5-carboxylic acid 
• 1024010-98-7 ethyl 2-((1S,4S)-5-(3-(trifluoromethyl)phenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)thiazole-5-carboxylate 
• 302963-42-4 C₁₉H₁₆BrClN₂O₂S 
• 1194552-16-3 ethyl 2-(p-tolylamino)thiazole-5-carboxylate 

Relevant academic research and scientific papers

Five-membered heteroaromatic derivative, preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to a five-membered heteroaromatic compound, a composition, a preparation method and application thereof. The compound or the composition can be used as an inhibitor of a retinoid-related orphan receptor [gamma]t (ROR [gamma]t). The invention also relates to a method for preparing the compound and the composition, and application of the compound and the composition in treatment or prevention of ROR [gamma]t-mediated cancers, inflammations or autoimmune diseases of mammals, especially human beings.

COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS

Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.

ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES

The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and in particular as glycosidase inhibitors.

PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES

The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-racemic, chiral acid.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein X1, X2, W, R1 to R5, L and m have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.

Regioselective functionalization of the thiazole scaffold using TMPMgCl?LiCl and TMP2Zn?2MgCl2?2LiCl

A general method for the synthesis of 2,4,5-trisubstituted thiazoles has been developed. Starting from commercially available 2-bromothiazole, successive metalations using TMPMgCl?LiCl or TMP2Zn?2MgCl 2?2LiCl lead to the correspondin

Ranging correlated motion (1.5 nm) of two coaxially arranged rotors mediated by helix inversion of a supramolecular transmitter

For a long-range transmission of motion between two movable parts apart from each other, transmitters that can precisely correlate these two motions should be properly incorporated into the system. However, such a motional relay is yet to be realized in a

5,6,7,8-tetrahydropyrido[2,3-D]pyrimidines

PCT No. PCT/US96/14822 Sec. 371 Date Feb. 26, 1999 Sec. 102(e) Date Feb. 26, 1999 PCT Filed Sep. 17, 1996 PCT Pub. No. WO97/41115 PCT Pub. Date Nov. 6, 1997Glutamic acid derivatives in which the amino group is substituted with a 2-amino-5,6,7,8-tetrahydro

Cyclopropyl derivative lipoxygenase inhibitors

Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.