41731-83-3

Basic information

• Product Name: Ethyl 2-bromothiazole-5-carboxylate
• Synonyms: ETHYL 2-BROMO-1,3-THIAZOLE-5-CARBOXYLATE;ETHYL 2-BROMOTHIAZOLE-5-CARBOXYLATE;RARECHEM AL BI 1435;2-BROMO-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ;Ethyl 2-bromothiazole-5-carboxylat;Ethyl 2-bromo-5-thiazolecarboxylate;ethyl 5-bromo-1,3-thiazole-2-carboxylate;5-Thiazolecarboxylic acid, 2-broMo-, ethyl ester
• CAS NO: 41731-83-3
• Molecular Formula: C₆H₆BrNO₂S
• Molecular Weight: 236.09
• EINECS: 1533716-785-6
• Product Categories: blocks;Bromides;Carboxes;Thiazoles;Esters;Thiazoles, Isothiazoles &Benzothiazoles;Thiazole;Thiazoles, Isothiazoles & Benzothiazoles;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;ThiazolesHeterocyclic Building Blocks;Building Blocks;C3 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 41731-83-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 216-217 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.581 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00448mmHg at 25°C
• Refractive Index: n20/D 1.5530(lit.)
• Storage Temp.: Keep Cold
• PKA: -0.98±0.10(Predicted)
• Water Solubility: Miscible is water.
• CAS DataBase Reference: Ethyl 2-bromothiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-bromothiazole-5-carboxylate(41731-83-3)
• EPA Substance Registry System: Ethyl 2-bromothiazole-5-carboxylate(41731-83-3)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 41731-83-3(Hazardous Substances Data)

Usage

Uses

Ethyl 2-bromothiazole-5-carboxylate is used in medicine, pharmaceutical intermediate

InChI:InChI=1/C6H6BrNO2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 623-49-4 ethyl cyanoformate 
• 32955-21-8 2-amino-thiazole-5-carboxylic acid ethyl ester 
• 12775-96-1 copper 

Downstream Products

• 54045-76-0 2-bromo-thiazole-5-carboxylic acid 
• 867315-08-0 2-(3-chloro-phenoxy)-thiazol-5-carboxylic acid ethyl ester 
• 400715-48-2 ethyl 2-(2fluorophenyl)thiazole-5-carboxylate 
• 302963-42-4 C₁₉H₁₆BrClN₂O₂S 
• 937729-02-7 Ethyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)-1,3-thiazole-5-carboxylate 
• 56355-59-0 Ethyl 2-(4-chlorophenoxy)thiazole-5-carboxylate 
• 56355-60-3 ethyl 2-phenylsulphanylthiazole-5-carboxylate 
• 864277-03-2 2-piperazin-1-yl-thiazol-5-carboxylic acid ethyl ester 
• 939803-89-1 2-[3-((1R,2S,3R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-2-{4-[1-(tert-butyl-dimethyl-silanyloxy)-hexyl]-phenyl}-5-chloro-cyclopentyl)-propyl]-thiazole-5-carboxylic acid ethyl ester 
• 591777-89-8 ethyl 2-anilino-1,3-thiazole-5-carboxylate 
• 886369-45-5 ethyl 2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylate 
• 886370-79-2 ethyl 2-(pyridin-2-yl)thiazole-5-carboxylate 
• 172678-67-0 ethyl 2-phenyl-1,3-thiazole-5-carboxylate 

Relevant articles and documents

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COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS

Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.

PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES

The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-racemic, chiral acid.