Technology Process of C24H31BrO6
There total 1 articles about C24H31BrO6 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,2R,4S,6R,7R)-10-Bromo-4-((R)-1-hydroxy-2-methyl-propyl)-4,9,9-trimethoxy-3-oxa-tricyclo[5.2.2.02,6]undec-10-en-8-one;
With
tetra-(n-butyl)ammonium iodide; sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
benzyl bromide;
In
tetrahydrofuran;
at 0 - 80 ℃;
for 4.16667h;
Inert atmosphere;
DOI:10.1021/ol4003724
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0);
In
toluene;
at 100 ℃;
for 48h;
Inert atmosphere;
DOI:10.1021/ol4003724
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / toluene / 48 h / 100 °C / Inert atmosphere
2.1: cerium(III) chloride / tetrahydrofuran / 1.5 h / -78 °C
2.2: 5 h / -78 °C / Inert atmosphere
3.1: 18-crown-6 ether; potassium hexamethylsilazane / toluene / 20.5 h / 0 - 130 °C / Inert atmosphere
4.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 11 h / 130 - 220 °C / Dean-Stark; Inert atmosphere
5.1: toluene-4-sulfonic acid / tetrahydrofuran; water / 2 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); cerium(III) chloride; 18-crown-6 ether; hydrazine hydrate; potassium hexamethylsilazane; toluene-4-sulfonic acid; potassium hydroxide;
In
tetrahydrofuran; water; toluene; diethylene glycol;
2.1: |Grignard Reaction / 2.2: |Grignard Reaction / 3.1: |Oxy-Cope Rearrangement;
DOI:10.1021/ol4003724
