{4-⁽⁵⁾-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt

Base Information

• Chemical Name: {4-⁽⁵⁾-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt
• CAS No.: 1235330-69-4
• Molecular Formula: C₂₂H₂₁N₃O₅S₄*H₃N
• Molecular Weight: 552.72

Synonyms:{4-⁽⁵⁾-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt

Chemical Property of {4-⁽⁵⁾-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt

Chemical Property:

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Technology Process of {4-⁽⁵⁾-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt

There total 5 articles about {4-⁽⁵⁾-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H21N3O2S3 → {4-(5)-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt (1235330-69-4)

Guidance literature:

C₂₂H₂₁N₃O₂S₃; With pyridine-SO₃ complex; In pyridine; at 20 ℃; for 0.0833333h;

With ammonium hydroxide; In pyridine; water;

Reference yield:

(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide (1000394-85-3) → {4-(5)-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt (1235330-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

2: pyridine; sulfur trioxide pyridine complex / 0.08 h / 20 °C

With pyridine; hydrogen; sulfur trioxide pyridine complex; palladium 10% on activated carbon; In methanol;

Reference yield:

Boc-Phe(p-NO2)-OH (33305-77-0) → {4-(5)-[2-phenylmethanesulfonylamino-2-(2-thiophen-2-ylthiazol-4-yl)ethyl]phenyl}sulfamic acid ammonium salt (1235330-69-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 5 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

6.1: pyridine; sulfur trioxide pyridine complex / 0.08 h / 20 °C

With pyridine; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

upstream raw materials:

Boc-Phe(p-NO₂)-OH

(S)-[3-diazo-1-(4-nitrobenzyl)-2-oxo-propyl]carbamic acid tert-butyl ester

(S)-2-(4-nitrophenyl)-1-(2-(thiophen-2-yl)thiazol-4-yl)ethan-1-amine hydrobromide

(S)-N-{2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}-1-phenylmethanesulfonamide

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