N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

Base Information

Chemical Name:N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide
CAS No.:493037-30-2
Molecular Formula:C₃₅H₂₇N₃O₆
Molecular Weight:585.616
Hs Code.:

<i>N</i>-[3-benzoyl-4-(2-<i>p</i>-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

Synonyms:N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

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Chemical Property of N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

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Technology Process of N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

There total 8 articles about N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 265648-28-0
N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide

: 847147-46-0
(E)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid chloride

: 493037-30-2
N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

Guidance literature:: In 1,4-dioxane; toluene; for 2h; Heating;
DOI:10.1021/jm010873j

Reference yield:

: 62806-39-7,58110-34-2
3-<5-(4-Nitrophenyl)-2-furyl>propenoic acid

: 493037-30-2
N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / toluene / 2 h / Heating

2: toluene; dioxane / 2 h / Heating

With thionyl chloride; In 1,4-dioxane; toluene;
DOI:10.1016/S0960-894X(02)00555-3 DOI:10.1016/S0968-0896(03)00064-6

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 493037-30-2
N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: (Ph₃P)4Pd; aq. K₂CO₃ / toluene; ethanol / 5 h / Heating

2: pyridine; piperidine / 2 h / Heating

3: SOCl₂ / toluene / 2 h / Heating

4: toluene; dioxane / 2 h / Heating

With piperidine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; In 1,4-dioxane; ethanol; toluene; 1: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00555-3