1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

Base Information

Chemical Name:1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine
CAS No.:1301628-73-8
Molecular Formula:C₄₁H₃₉N₃O₇S
Molecular Weight:717.843
Hs Code.:

Synonyms:1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

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Chemical Property of 1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

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Technology Process of 1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

There total 4 articles about 1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1301628-72-7
1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

: 1005-56-7
phenylcarbonochloridothioate

: 1301628-73-8
1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

Guidance literature:: With 1-methyl-1H-imidazole; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jo200073q

Reference yield:

: 945382-94-5
C₂₆H₃₀O₇

: 1301628-73-8
1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.75 h / Reflux

1.2: 0 - 20 °C

2.1: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

3.1: 1-methyl-1H-imidazole / dichloromethane / 1.5 h / 20 °C

With 1-methyl-1H-imidazole; N,O-bis-(trimethylsilyl)-acetamide; water; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo200073q

Reference yield:

: 945382-92-3
4-C-allyl-3,5-di-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranose

: 1301628-73-8
1-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N4-benzoyl-5-methylcytosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid; acetic acid / dichloromethane / 0.5 h / 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.75 h / Reflux

2.2: 0 - 20 °C

3.1: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

4.1: 1-methyl-1H-imidazole / dichloromethane / 1.5 h / 20 °C

With 1-methyl-1H-imidazole; N,O-bis-(trimethylsilyl)-acetamide; trifluorormethanesulfonic acid; water; acetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo200073q