2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

Base Information

Chemical Name:2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine
CAS No.:1190979-68-0
Molecular Formula:C₂₄H₃₃ClN₄O₃S
Molecular Weight:493.07
Hs Code.:

Synonyms:2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

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Chemical Property of 2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

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Technology Process of 2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

There total 11 articles about 2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 479611-96-6
4-(methylsulfonyl)piperidine hydrochloride

: 1190979-65-7
2-(4-(2-chloro-4-(chloromethyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

: 1190979-68-0
2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

Guidance literature:: With caesium carbonate; In acetonitrile; at 60 ℃; for 12h;

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1190979-68-0
2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 3 h / Heating; Reflux

2: caesium carbonate / acetonitrile / 0.05 h / 180 °C / Microwave irradiation

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

4: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

5: caesium carbonate / acetonitrile / 12 h / 60 °C

With lithium aluminium tetrahydride; sulfuric acid; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1190979-68-0
2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 0.05 h / 180 °C / Microwave irradiation

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

3: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

4: caesium carbonate / acetonitrile / 12 h / 60 °C

With lithium aluminium tetrahydride; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;