4-(Methylsulfonyl)-piperidine HCl

Base Information

• Chemical Name: 4-(Methylsulfonyl)-piperidine HCl
• CAS No.: 479611-96-6
• Molecular Formula: C6H13NO2S.ClH
• Molecular Weight: 199.702
• Hs Code.: 2933399090
• Mol file: 479611-96-6.mol

Synonyms:4-methanesulfonyl-piperidine hydrochloride salt;ethyl 4-mesyloxy crotonate;4-methanesulfonyl-piperidine hydrochloric acid salt;4-Methylsulfonyl-piperidine hydrochloride;4-methanesulfonylpiperidine hydrochloride;

Chemical Property of 4-(Methylsulfonyl)-piperidine HCl

Chemical Property:

• PSA: 54.55000
• LogP: 1.99460

Purity/Quality:

97% ^*data from raw suppliers

4-methanesulfonylpiperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Methylsulfonyl)-piperidine HCl

There total 5 articles about 4-(Methylsulfonyl)-piperidine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methanesulfonylpiperidine-1-carboxylic acid tert-butyl ester (189205-49-0) → 4-(methylsulfonyl)piperidine hydrochloride (479611-96-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃;

Reference yield:

4-methylsulfanylpiperidine-1-carboxylic acid tert-butyl ester (208245-69-6) → 4-(methylsulfonyl)piperidine hydrochloride (479611-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 0.03 h / Reflux

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(methylsulfonyl)piperidine hydrochloride (479611-96-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2.17 h / 0 - 20 °C

2: methanol / 15 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 0.03 h / Reflux

With hydrogenchloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; dichloromethane;

upstream raw materials:

4-methanesulfonylpiperidine-1-carboxylic acid tert-butyl ester

t-butyl 4-hydroxy piperidine-1-carboxylate

4-methylsulfanylpiperidine-1-carboxylic acid tert-butyl ester

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

Downstream raw materials:

2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

2-fluoro-6-(4-methanesulfonylpiperidine-1-yl)benzaldehyde

trans-4-{4-[4-(4-methanesulfonyl-piperidin-1-yl)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanol

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