4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole

Base Information

• Chemical Name: 4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole
• CAS No.: 192987-42-1
• Molecular Formula: C₃₉H₃₄N₂O₂
• Molecular Weight: 562.711
• Mol file: 192987-42-1.mol

Synonyms:4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole

Chemical Property of 4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole

There total 3 articles about 4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Hydroxy-1-tetralone (28315-93-7) → 4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole (192987-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃ / CHCl₃; methanol / 3 h / Heating

2: 1.) EtMgBr / 1.) Et₂O, CH₂Cl₂, RT, 1 h, 2.) Et₂O, CH₂Cl₂, overnight

With ethylmagnesium bromide; potassium carbonate; In methanol; chloroform;

DOI:10.1021/jm960642q

Reference yield:

benzyl bromide (100-39-0) → 4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole (192987-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃ / CHCl₃; methanol / 3 h / Heating

2: 1.) EtMgBr / 1.) Et₂O, CH₂Cl₂, RT, 1 h, 2.) Et₂O, CH₂Cl₂, overnight

With ethylmagnesium bromide; potassium carbonate; In methanol; chloroform;

DOI:10.1021/jm960642q

Reference yield:

N-trityl-4(5)-iodoimidazole (96797-15-8) + 5-benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-one (90401-60-8) → 4-{1-[5-(benzyloxy)-1-hydroxy]-1,2,3,4-tetrahydronaphthyl}-N-(triphenylmethyl)imidazole (192987-42-1)

Guidance literature:

With ethylmagnesium bromide; Yield given. Multistep reaction; 1.) Et₂O, CH₂Cl₂, RT, 1 h, 2.) Et₂O, CH₂Cl₂, overnight;

DOI:10.1021/jm960642q

upstream raw materials:

N-trityl-4⁽⁵⁾-iodoimidazole

5-benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-one

5-Hydroxy-1-tetralone

benzyl bromide

Downstream raw materials:

4-[3,4-dihydro-5-(benzyloxy)-1-naphthyl]-1H-imidazole