(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide
CAS No.:1610862-13-9
Molecular Formula:C₃₄H₃₈Cl₂F₂N₄O₉S
Molecular Weight:787.666
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

There total 6 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1610862-14-0
4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-methylsulfonamido)benzoic acid

: 1610862-13-9
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: benzyl 4-methoxy-3-nitrobenzoate

: 1610862-13-9
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride; iron / water; ethanol / 2 h / 80 °C

2: pyridine / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 1551.49 Torr

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; iron; potassium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1610862-15-1
benzyl 4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)benzoate

: 1610862-13-9
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)methylsulfonamido)-benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 1551.49 Torr

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;