1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide

Base Information

Chemical Name:1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide
CAS No.:1416265-57-0
Molecular Formula:C₁₉H₁₅F₄N₃O₄S
Molecular Weight:457.405
Hs Code.:

Synonyms:1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide

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Chemical Property of 1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide

There total 7 articles about 1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416265-24-1
1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide

: 1416265-57-0
1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide

Guidance literature:: With Oxone; sodium hydrogencarbonate; In acetone; at 50 ℃;

Reference yield:

: 2521-99-5
2-(4-fluorophenylamino)acetic acid ethyl ester

: 1416265-57-0
1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 20 °C

2.1: potassium ethoxide / benzene / 0 °C

2.2: 2 h / 60 °C

3.1: water; lithium hydroxide / 1,4-dioxane; methanol / 50 °C

4.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 40 °C

5.1: potassium carbonate / acetone / 3 h / Reflux

6.1: Oxone; sodium hydrogencarbonate / acetone / 50 °C

With pyridine; Oxone; potassium ethoxide; water; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; acetone; benzene;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1416265-57-0
1-(4-fluorophenyl)-N-methoxy-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium acetate / ethanol / 2 h / 80 °C

2.1: tetrahydrofuran / 20 °C

3.1: potassium ethoxide / benzene / 0 °C

3.2: 2 h / 60 °C

4.1: water; lithium hydroxide / 1,4-dioxane; methanol / 50 °C

5.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 40 °C

6.1: potassium carbonate / acetone / 3 h / Reflux

7.1: Oxone; sodium hydrogencarbonate / acetone / 50 °C

With pyridine; Oxone; potassium ethoxide; water; sodium acetate; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; acetone; benzene;