(S)-3-N-CBZ-AMINOPYRROLIDINE

Base Information

• Chemical Name: (S)-3-N-CBZ-AMINOPYRROLIDINE
• CAS No.: 176970-12-0
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.271
• Mol file: 176970-12-0.mol

Synonyms:Carbamicacid, 3-pyrrolidinyl-, phenylmethyl ester, (S)-;(S)-3-Benzyloxycarbonylaminopyrrolidine;

Chemical Property of (S)-3-N-CBZ-AMINOPYRROLIDINE

Chemical Property:

• Vapor Pressure: 4.69E-06mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 382.5 °C at 760 mmHg
• Flash Point: 185.1 °C
• PSA: 50.36000
• Density: 1.16g/cm³
• LogP: 1.99440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-N-Cbz-aminopyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-N-CBZ-AMINOPYRROLIDINE

There total 6 articles about (S)-3-N-CBZ-AMINOPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-1-allyl-3-(benzyloxycarbonylamino)pyrrolidine (176970-10-8) → (S)-benzyl pyrrolidin-3-ylcarbamate (176970-12-0)

Guidance literature:

With acetic acid; palladium on activated charcoal; In water; at 100 ℃; for 1.5h;

Reference yield:

(S)-2-(((benzyloxy)carbonyl)amino)butane-1,4-diyl dimethanesulfonate (176970-05-1) → (S)-benzyl pyrrolidin-3-ylcarbamate (176970-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.60 g / 3 h / 40 °C

2: 92 percent / AcOH / 10percent Pd/C / H₂O / 1.5 h / 100 °C

With acetic acid; palladium on activated charcoal; In water;

Reference yield:

[(1S)-3-hydroxy-1-(hydroxymethyl)propyl]carbamic acid phenylmethyl ester (118219-23-1) → (S)-benzyl pyrrolidin-3-ylcarbamate (176970-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 16.9 g / Et₃N / ethyl acetate / 1 h / -20 - -5 °C

2: 2.60 g / 3 h / 40 °C

3: 92 percent / AcOH / 10percent Pd/C / H₂O / 1.5 h / 100 °C

With acetic acid; triethylamine; palladium on activated charcoal; In water; ethyl acetate;

upstream raw materials:

(S)-1-allyl-3-(benzyloxycarbonylamino)pyrrolidine

dimethyl (2S)-2-[(phenylmethoxy)carbonylamino]-butane-1,4-dioate

N-Cbz-L-Asp

[(1S)-3-hydroxy-1-(hydroxymethyl)propyl]carbamic acid phenylmethyl ester

Downstream raw materials:

tert-butyl (S)-3-(((benzyloxy)carbonyl)amino)pyrrolidine-1-carboxylate