5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

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Chemical Name:5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine
CAS No.:1392151-83-5
Molecular Formula:C₂₉H₃₃F₂N₇OS
Molecular Weight:565.69
Hs Code.:

Synonyms:5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

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Chemical Property of 5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

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Technology Process of 5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

There total 8 articles about 5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1392151-79-9
N-(5-((3,5-difluorophenyl)thio)-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide

: 1392151-83-5
5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

Guidance literature:: N-(5-((3,5-difluorophenyl)thio)-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 90 ℃; for 20h; Inert atmosphere;

With water; sodium hydroxide; at 25 ℃; for 1h;

Reference yield: 17.0%

: N-(5-((3,5-difluorophenyl)amino)-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

: 1392151-83-5
5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

Guidance literature:: N-(5-((3,5-difluorophenyl)amino)-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 90 ℃; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 0 - 25 ℃;

Reference yield:

: 1034975-61-5
4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoic acid

: 1392151-83-5
5-((3,5-difluorophenyl)thio)-N-(4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C

1.2: -20 - 20 °C

2.1: methanol; triethylamine / 20 - 65 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 h / 0 - 90 °C / Inert atmosphere

3.2: 1 h / 25 °C

With methanol; lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;