(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

Base Information

Chemical Name:(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester
CAS No.:479496-21-4
Molecular Formula:C₅₂H₈₀N₂O₈Si₂
Molecular Weight:917.387
Hs Code.:

(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

Synonyms:(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

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Chemical Property of (E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

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Technology Process of (E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

There total 8 articles about (E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 479496-20-3
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

: 705-59-9
2-hydroxy-3-phenylpropionamide

: 479496-21-4
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

Guidance literature:: (E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester; With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 6h;

2-hydroxy-3-phenylpropionamide; With dmap; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; In dichloromethane; for 24h;

Reference yield:

: 2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

: 479496-21-4
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 mg / imidazole / dimethylformamide / 16 h

2: aq. LiOH; aq. H₂O₂ / tetrahydrofuran; methanol / 6 h / 20 °C

3: 12 mg / EDCI*MeI; DMAP / CH₂Cl₂ / 24 h

With 1H-imidazole; dmap; lithium hydroxide; dihydrogen peroxide; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja027150p

Reference yield:

: 479496-20-3
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

: 479496-21-4
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethylsilanyloxy)-non-4-enoic acid 1-carbamoyl-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH; aq. H₂O₂ / tetrahydrofuran; methanol / 6 h / 20 °C

2: 12 mg / EDCI*MeI; DMAP / CH₂Cl₂ / 24 h

With dmap; lithium hydroxide; dihydrogen peroxide; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja027150p