(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

Base Information

Chemical Name:(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester
CAS No.:479496-20-3
Molecular Formula:C₅₀H₇₇NO₆SSi₂
Molecular Weight:876.401
Hs Code.:

Synonyms:(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

There total 5 articles about (E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74974-37-1
tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-oxoethyl]carbamate

: 479496-20-3
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / -78 - 0 °C

2: Cl₂(PCy₃)(IMesH₂)Ru=CHPh / CH₂Cl₂ / 1.5 h / 45 °C

3: 56 mg / imidazole / dimethylformamide / 16 h

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja027150p

Reference yield:

: 100-53-8
phenylmethanethiol

: 479496-20-3
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₂BOTf; NEt₃ / CH₂Cl₂

1.2: BuLi; AlMe₃ / tetrahydrofuran

2.1: Cl₂(PCy₃)(IMesH₂)Ru=CHPh / CH₂Cl₂ / 1.5 h / 45 °C

3.1: 56 mg / imidazole / dimethylformamide / 16 h

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja027150p

Reference yield:

: 479495-56-2
(S,S)-[1-(4-tert-butoxy-benzyl)-2-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

: 479496-20-3
(E)-2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Cl₂(PCy₃)(IMesH₂)Ru=CHPh / CH₂Cl₂ / 1.5 h / 45 °C

2: 56 mg / imidazole / dimethylformamide / 16 h

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja027150p