C₁₇H₁₂ClF₃O₅

Base Information

• Chemical Name: C₁₇H₁₂ClF₃O₅
• CAS No.: 1434871-02-9
• Molecular Formula: C₁₇H₁₂ClF₃O₅
• Molecular Weight: 388.727
• Mol file: 1434871-02-9.mol

Synonyms:C₁₇H₁₂ClF₃O₅

Chemical Property of C₁₇H₁₂ClF₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₂ClF₃O₅

There total 1 articles about C₁₇H₁₂ClF₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methoxyphenyl 2-chloroacetate (30287-15-1) + 3-methoxy-2,4,5-trifluorobenzoic acid (112811-65-1) → C17H12ClF3O5 (1434871-02-9)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 50 ℃; for 14h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.03.064

Reference yield: 96.0%

C17H12ClF3O5 (1434871-02-9) → C15H11F3O4 (1434871-08-5)

Guidance literature:

With sodium acetate; In methanol; for 2h; Reflux;

DOI:10.1016/j.bmc.2013.03.064

Reference yield:

C17H12ClF3O5 (1434871-02-9) → C16H13F3O3 (1434871-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / methanol / 2 h / Reflux

2: Methyltriphenylphosphonium bromide; potassium tert-butylate / tetrahydrofuran / 24 h / 20 °C

With potassium tert-butylate; sodium acetate; Methyltriphenylphosphonium bromide; In tetrahydrofuran; methanol; 2: |Wittig Olefination;

DOI:10.1016/j.bmc.2013.03.064

upstream raw materials:

2-methoxyphenyl 2-chloroacetate

3-methoxy-2,4,5-trifluorobenzoic acid

Downstream raw materials:

C₁₅H₁₁F₃O₄

C₁₆H₁₃F₃O₃

Refernces

• 1、 Ghinet, Alina,Tourteau, Aurélien,Rigo, Beno?t,Stocker, Vivien,Leman, Marie,Farce, Amaury,Dubois, Jo?lle,Gautret, Philippe. "Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin". . p. 2932 - 2940. Retrieved 2013/07/05.