30287-15-1

Basic information

• Product Name: 2-methoxyphenyl chloroacetate
• Synonyms: 2-Methoxyphenyl chloroacetate
• CAS NO: 30287-15-1
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.619
• Mol File: 30287-15-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 246.6°C at 760 mmHg
• Flash Point: 99°C
• Density: 1.234g/cm³
• Vapor Pressure: 0.0269mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 2-methoxyphenyl chloroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxyphenyl chloroacetate(30287-15-1)
• EPA Substance Registry System: 2-methoxyphenyl chloroacetate(30287-15-1)

Safety Data

• Hazardous Substances Data: 30287-15-1(Hazardous Substances Data)

Upstream product

• 90-05-1 2-methoxy-phenol 
• 79-11-8 chloroacetic acid 
• 79-04-9 chloroacetyl chloride 
• 10025-87-3 trichlorophosphate 
• 1169877-08-0 (+)-guaiacol 2-(4-isobutylphenyl)propionate 
• 127354-55-6 C₇H₇O₂^(1-)*Br^(1-)*Mg⁽²⁺⁾ 

Downstream Products

• 55761-46-1 3-Hydroxy-4-methoxy-α-chloroacetophenone 
• 90-05-1 2-methoxy-phenol 
• 1257845-27-4 2-methoxyphenyl-2-[2(2,6-dichlorophenylamino)phenyl]ethanoyloxy ethanoate 
• 1169877-08-0 (+)-guaiacol 2-(4-isobutylphenyl)propionate 
• 874812-62-1 2-methoxy-5-(3,4,5-trimethoxybenzoyl)phenyl 2-chloroacetate 
• 1647107-51-4 8-hydroxy-3,5,6,7,10,11,12-heptamethoxybenzo[a]aceanthrylen-2-yl chloroacetate 
• 1647107-55-8 C₂₈H₂₉ClO₉ 
• 1647107-56-9 5-(3,4-dimethoxybenzoyl)-2-methoxyphenyl chloroacetate 
• 1647107-57-0 2-methoxy-5-(2-methoxybenzoyl)phenyl chloroacetate 
• 1647107-59-2 5-(3,5-dimethoxy-4-methylbenzoyl)-2-methoxyphenyl chloroacetate 
• 1647107-60-5 8-hydroxy-3,5,7,10,12-pentamethoxy-6,11-dimethylbenzo[a]aceanthrylen-2-yl chloroacetate 

Relevant articles and documents

Antihyperlipidemic studies of newly synthesized phenolic derivatives: In silico and in vivo approaches

Background: Hyperlipidemia is a worth-mentioning risk factor in quickly expanding cardiovascular diseases, including myocardial infarction and, furthermore, in stroke. Methods: The present work describes the synthesis of phenolic derivatives 4a–e and 6a–c

PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE

The present disclosure relates to a process for the preparation of 4,5-dihydroxy-2-(4-methylbenzyl)isophthalonitrile, to use of a compound which is 2-methoxy-5-(4-methylbenzyl)phenol, (3-hydroxy-4-methoxyphenyl)(p-tolyl)methanone, 2-methoxy-5-(4-methylben

Substituted phenyl[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetates/acetamides as alkaline phosphatase inhibitors: Synthesis, computational studies, enzyme inhibitory kinetics and DNA binding studies

Substituted phenyl[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetates/acetamides 9a-j were synthesized as alkaline phosphatase inhibitors. Phenyl acetic acid 1 through a series of reactions was converted into 5-benzyl-1,3,4-oxadiazole-2-thione 4. The intermediate oxadiazole 4 was then reacted with chloroacetyl derivatives of phenols 6a-f and anilines derivatives 8a-d to afford the title oxadiazole derivatives 9a-j. All of the title compounds 9a-j were evaluated for their inhibitory activity against human alkaline phosphatise (ALP). It was found that compounds 9a-j exhibited good to excellent alkaline phosphatase inhibitory activity especially 9h displayed potent activity with IC50 value 0.420 ± 0.012 μM while IC50 value of standard (KH2PO4) was 2.80 μM. The enzyme inhibitory kinetics of most potent inhibitor 9h was determined by Line-weaever Burk plots showing non-competitive mode of binding with enzyme. Molecular docking studies were performed against alkaline phosphatase enzyme (1EW2) to check the binding affinity of the synthesized compounds 9a-j against target protein. The compound 9h exhibited excellent binding affinity having binding energy value (?7.90 kcal/mol) compared to other derivatives. The brine shrimp viability assay results proved that derivative 9h was non-toxic at concentration used for enzyme assay. The lead compound 9h showed LD50 106.71 μM while the standard potassium dichromate showed LD50 0.891 μM. The DNA binding interactions of the synthesized compound 9h was also determined experimentally by spectrophotometric and electrochemical methods. The compound 9h was found to bind with grooves of DNA as depicted by both UV–Vis spectroscopy and cyclic voltammetry with binding constant values 7.83 × 103 and 7.95 × 103 M?1 respectively revealing significant strength of 9h-DNA complex. As dry lab and wet lab results concise each other it was concluded that synthesized compounds, especially compound 9h may serve as lead compound to design most potent inhibitors of human ALP.