4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

Base Information

• Chemical Name: 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester
• CAS No.: 1073543-62-0
• Molecular Formula: C₂₆H₃₂ClN₃O₂
• Molecular Weight: 454.012

Synonyms:4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

Chemical Property of 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

There total 6 articles about 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester (1073543-65-3) → 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester (1073543-62-0)

Guidance literature:

4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester; With ammonium acetate; sodium cyanoborohydride; In methanol; at 0 ℃; for 0.25h; Inert atmosphere;

With titanium(III) chloride; In methanol; at 0 - 20 ℃; for 3.16667h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.8b00462

Reference yield:

o-tolylbenzoic acid (7148-03-0) → 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester (1073543-62-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: thionyl chloride / 5.5 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3.1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 6 h / Inert atmosphere; Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: pyridine; hydroxylamine hydrochloride / water / 20 °C / Inert atmosphere

6.1: ammonium acetate; sodium cyanoborohydride / methanol / 0.25 h / 0 °C / Inert atmosphere

6.2: 3.17 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; thionyl chloride; hydroxylamine hydrochloride; ammonium acetate; sodium cyanoborohydride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; benzene;

DOI:10.1021/acsmedchemlett.8b00462

Reference yield:

4'-methylbiphenyl-2-carboxylic acid chloride (114772-35-9) → 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester (1073543-62-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 6 h / Inert atmosphere; Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: pyridine; hydroxylamine hydrochloride / water / 20 °C / Inert atmosphere

5.1: ammonium acetate; sodium cyanoborohydride / methanol / 0.25 h / 0 °C / Inert atmosphere

5.2: 3.17 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; hydroxylamine hydrochloride; ammonium acetate; sodium cyanoborohydride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; benzene;

DOI:10.1021/acsmedchemlett.8b00462

upstream raw materials:

4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

o-tolylbenzoic acid

4'-methylbiphenyl-2-carboxylic acid chloride

tert-butyl 4'-methyl-2-biphenylcarboxylate

Downstream raw materials:

4'-5-[((S)-2-acetylsulfanylmethyl-4-methylpentanoylamino)methyl]-2-butyl-4-chloroimidazol-1-ylmethylbiphenyl-2-carboxylic acid t-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1073543-62-0 4’-(5-aminomethyl-2-butyl-4-chloroimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send