4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

Base Information

Chemical Name:4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester
CAS No.:1073543-65-3
Molecular Formula:C₂₆H₃₀ClN₃O₃
Molecular Weight:467.996
Hs Code.:

Synonyms:4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

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Chemical Property of 4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

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Technology Process of 4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

There total 5 articles about 4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 133694-34-5
4’-(2-butyl-4-chloro-5-formylimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

: 1073543-65-3
4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In water; at 20 ℃; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00462

Reference yield:

: 7148-03-0
o-tolylbenzoic acid

: 1073543-65-3
4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 5.5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 6 h / Inert atmosphere; Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: pyridine; hydroxylamine hydrochloride / water / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/acsmedchemlett.8b00462

Reference yield:

: 114772-35-9
4'-methylbiphenyl-2-carboxylic acid chloride

: 1073543-65-3
4’-[2-butyl-4-chloro-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

2: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 6 h / Inert atmosphere; Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: pyridine; hydroxylamine hydrochloride / water / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; hydroxylamine hydrochloride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/acsmedchemlett.8b00462