(1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride

Base Information

Chemical Name:(1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride
CAS No.:1207436-42-7
Molecular Formula:C₁₄H₁₇Cl₂NO*ClH
Molecular Weight:322.662
Hs Code.:

Synonyms:(1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride

Chemical Property:

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Technology Process of (1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride

There total 8 articles about (1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1207439-12-0
tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-oxopropyl]piperidine-1-carboxylate

: 1207436-42-7
(1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride

Guidance literature:: With hydrogenchloride; ethanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-43-4
tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate

: 1207436-42-7
(1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide; water / 5 h / Reflux

2.1: sodium hydroxide / water

2.2: 20 h / 20 °C

2.3: pH Ca_. 3

3.1: tetrahydrofuran / 2 h / 20 °C

4.1: tetrahydrofuran; diethyl ether / 0 °C

5.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; ethanol; water; hydrogen bromide; sodium hydroxide; In tetrahydrofuran; diethyl ether; water;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-51-4
(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

: 1207436-42-7
(1RS)-1-(3,4-dichlorophenyl)-1-(piperidin-4-yl)propan-2-one monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water

1.2: 20 h / 20 °C

1.3: pH Ca_. 3

2.1: tetrahydrofuran / 2 h / 20 °C

3.1: tetrahydrofuran; diethyl ether / 0 °C

4.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; ethanol; sodium hydroxide; In tetrahydrofuran; diethyl ether; water;
DOI:10.1016/j.bmc.2013.05.025