Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester
• CAS No.: 132539-99-2
• Molecular Formula: C₁₀H₁₂F₃NO₅S₂
• Molecular Weight: 347.336

Synonyms:Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester

Chemical Property of Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester

Chemical Property:

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Technology Process of Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester

There total 2 articles about Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzenesulfonyl chloride (98-09-9) → Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester (132539-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

2: triethylamine / CH₂Cl₂ / 0.5 h

With triethylamine; In dichloromethane;

DOI:10.1021/jm00108a019

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 2-ethanol (59724-60-6) → Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester (132539-99-2)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h;

DOI:10.1021/jm00108a019

Reference yield: 70.0%

Trifluoro-methanesulfonic acid 2-(benzenesulfonyl-methyl-amino)-ethyl ester (132539-99-2) + (3aS,7aS)-2-[1-(3,4-Dimethoxy-phenyl)-pent-4-enyl]-3a,4,5,6,7,7a-hexahydro-1H-benzoimidazole (219143-77-8) → N-[3-(3,4-dimethoxy-phenyl)-3-(3a,4,5,6,7,7a-hexahydro-1H-benzoimidazol-2-yl)-hept-6-enyl]-N-methyl-benzenesulfonamide (219143-78-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; 1.) - 25 deg C, 15 min; 2.) -78 deg C, 12 h;

DOI:10.1016/S0040-4039(98)02032-2

upstream raw materials:

trifluoromethylsulfonic anhydride

2-ethanol

benzenesulfonyl chloride

Downstream raw materials:

N-[3-(3,4-dimethoxy-phenyl)-3-(3a,4,5,6,7,7a-hexahydro-1H-benzoimidazol-2-yl)-hept-6-enyl]-N-methyl-benzenesulfonamide

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