(S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

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Chemical Name:(S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester
CAS No.:103346-42-5
Molecular Formula:C₃₃H₅₂N₄O₉
Molecular Weight:648.797
Hs Code.:

Synonyms:(S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

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Chemical Property of (S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

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Technology Process of (S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

There total 5 articles about (S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 90139-74-5
4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyric acid

: 103346-42-5
(S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00160a014

Reference yield:

: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

: 103346-42-5
(S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dimethylformamide / 0.33 h

2: Et₃N / dimethylformamide / 0.5 h

3: 89 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

4: 99 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

With barium dihydroxide; diphenylphosphoranyl azide; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014

Reference yield:

: C₁₇H₂₃NO₆

: 103346-42-5
(S)-2-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / dimethylformamide / 0.5 h

2: 89 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

3: 99 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

With barium dihydroxide; diphenylphosphoranyl azide; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014