(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one
CAS No.:131451-97-3
Molecular Formula:C₂₂H₃₃NO₃
Molecular Weight:359.509
Hs Code.:

Synonyms:(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one

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Chemical Property of (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one

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Technology Process of (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one

There total 17 articles about (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 181025-91-2
Benzyl-[(S)-2-cyclohexyl-1-((2S,3S)-3-isobutyl-oxiranyl)-ethyl]-amine

: 131451-97-3
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one

Guidance literature:: at 60 ℃; for 48h;
DOI:10.1016/0040-4039(96)00874-X

Reference yield: 62.0%

: 1068-55-9
isopropylmagnesium chloride

: 131451-95-1
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-oxiran-2-yl>oxazolidin-2-one

: 131451-97-3
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one

Guidance literature:: With copper(l) iodide; In diethyl ether; at 0 ℃; for 1.5h;
DOI:10.1246/cl.1990.1709

Reference yield:

: 35166-78-0
cyclohexylmethyl magnesium bromide

: 131451-97-3
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / tetrahydrofuran / -85 °C

2: 64 percent / tetramethyl ammonium triacetoxyborohydride, AcOH, 4 Angstroem mol. sieves / CH₂Cl₂ / 8 h

3: 75 percent / 48 h / 60 °C

With 4 A molecular sieve; acetic acid; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0040-4039(96)00874-X