(S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide

Base Information

Chemical Name:(S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide
CAS No.:1381846-15-6
Molecular Formula:C₁₇H₂₀F₂N₄O₂
Molecular Weight:350.368
Hs Code.:

Synonyms:(S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide

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Chemical Property of (S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide

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Technology Process of (S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide

There total 10 articles about (S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1730-91-2
(S)-2-Methylbutyric acid

: 5-(aminomethyl)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)benzamide dihydrochloride

: 1381846-15-6
(S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/acs.jmedchem.5b01249

Reference yield:

: 1381846-30-5
methyl 5-(aminomethyl)-2-(difluoromethyl)benzoate hydrochloride

: 1381846-15-6
(S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 0.5 h / 20 °C

2.1: sodium hydroxide / water; 1,4-dioxane / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C

3.2: 60 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01249

Reference yield:

: 1381846-31-6
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

: 1381846-15-6
(S)-2-(difluoromethyl)-N-(1H-imidazol-2-yl)-5-((2-methylbutanamido)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; 1,4-dioxane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C

2.2: 60 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01249