methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

Base Information

Chemical Name:methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate
CAS No.:1381846-31-6
Molecular Formula:C₁₅H₁₉F₂NO₄
Molecular Weight:315.317
Hs Code.:

Synonyms:methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

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Chemical Property of methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

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Technology Process of methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

There total 5 articles about methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1381846-30-5
methyl 5-(aminomethyl)-2-(difluoromethyl)benzoate hydrochloride

: 1381846-31-6
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 42872-74-2
3-bromo-4-methyl-benzonitrile

: 1381846-31-6
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / tetrachloromethane / 48 h / 95 °C

2: silver tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

3: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 72 h / 20 - 80 °C / 1035.1 Torr / Inert atmosphere

4: hydrogenchloride; hydrogen / palladium on activated charcoal / water; methanol / 20 °C / 2062.71 Torr / Inert atmosphere

5: triethylamine / methanol / 0.5 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; silver tetrafluoroborate; 1,3-bis-(diphenylphosphino)propane; hydrogen; triethylamine; palladium on activated charcoal; palladium diacetate; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1381846-22-5
3-bromo-4-(dibromomethyl)benzonitrile

: 1381846-31-6
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-(difluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: silver tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 72 h / 20 - 80 °C / 1035.1 Torr / Inert atmosphere

3: hydrogenchloride; hydrogen / palladium on activated charcoal / water; methanol / 20 °C / 2062.71 Torr / Inert atmosphere

4: triethylamine / methanol / 0.5 h / 20 °C

With hydrogenchloride; silver tetrafluoroborate; 1,3-bis-(diphenylphosphino)propane; hydrogen; triethylamine; palladium on activated charcoal; palladium diacetate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;