Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester
• CAS No.: 181378-99-4
• Molecular Formula: C₂₇H₃₀F₃NO₁₁S
• Molecular Weight: 633.597

Synonyms:Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

Chemical Property of Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

There total 5 articles about Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R,4S,4aR)-5-(4-Methoxybenzyl)-2-<(4-methoxybenzyl)oxy>-3,4-bis<(methoxymethyl)oxy>-3,4,4a,5-tetrahydro<1,3>dioxolo<4,5-j>phenanthridin-6(2H)-one (137423-23-5) → Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester (181378-99-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / H₂ / 5percent Pd-C / ethanol; ethyl acetate / Ambient temperature

2: pyridine; CH₂Cl₂ / 0 °C

3: 18-crown-6 / benzene / Ambient temperature

4: 98 percent / MeONa / methanol / 0 °C

5: pyridine; CH₂Cl₂ / 0 °C

With 18-crown-6 ether; hydrogen; sodium methylate; palladium on activated charcoal; In pyridine; methanol; ethanol; dichloromethane; ethyl acetate; benzene;

DOI:10.3987/COM-96-7481

Reference yield:

Acetic acid (2S,3R,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester (181225-00-3) → Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester (181378-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / MeONa / methanol / 0 °C

2: pyridine; CH₂Cl₂ / 0 °C

With sodium methylate; In pyridine; methanol; dichloromethane;

DOI:10.3987/COM-96-7481

Reference yield:

Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester (181224-98-6) → Trifluoro-methanesulfonic acid (2S,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester (181378-99-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 18-crown-6 / benzene / Ambient temperature

2: 98 percent / MeONa / methanol / 0 °C

3: pyridine; CH₂Cl₂ / 0 °C

With 18-crown-6 ether; sodium methylate; In pyridine; methanol; dichloromethane; benzene;

DOI:10.3987/COM-96-7481

upstream raw materials:

trifluoromethylsulfonic anhydride

(2S,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

(2R,3R,4S,4aR)-5-(4-Methoxybenzyl)-2-<(4-methoxybenzyl)oxy>-3,4-bis<(methoxymethyl)oxy>-3,4,4a,5-tetrahydro<1,3>dioxolo<4,5-j>phenanthridin-6(2H)-one

Acetic acid (2S,3R,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

Downstream raw materials:

(3R,4S,4aR,11bR)-5-(4-Methoxy-benzyl)-3,4-bis-methoxymethoxy-3,4a,5,11b-tetrahydro-4H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

(3R,4S,4aR,11bR)-3,4-Dihydroxy-5-(4-methoxy-benzyl)-3,4a,5,11b-tetrahydro-4H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

C₂₂H₂₁NO₇

Acetic acid (1R,2S,3S,4S,4aR,11bR)-2,3,4-triacetoxy-5-(4-methoxy-benzyl)-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-1-yl ester

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