4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

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Chemical Name:4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol
CAS No.:1442371-72-3
Molecular Formula:C₂₈H₃₀N₆O₂S
Molecular Weight:514.651
Hs Code.:

Synonyms:4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

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Chemical Property of 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

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Technology Process of 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

There total 3 articles about 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1442371-82-5
10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-pyrrolidin-1-yl-10H-phenothiazine

: 1442371-72-3
4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

Guidance literature:: With hydrogenchloride; In ethanol; water; Reflux;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 1387627-09-9
1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol

: 1442371-72-3
4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 2.5 h / 0 - 20 °C / Inert atmosphere

2.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 100 - 110 °C / Inert atmosphere; Alkaline conditions

3.1: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; XPhos; In ethanol; water; N,N-dimethyl-formamide; toluene; 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 1442371-78-9
10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

: 1442371-72-3
4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-pyrrolidin-1-yl-10H-phenothiazin-10-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 100 - 110 °C / Inert atmosphere; Alkaline conditions

2: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In ethanol; water; toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034