10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

Base Information

Chemical Name:10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine
CAS No.:1442371-78-9
Molecular Formula:C₃₁H₂₈ClN₅O₂S
Molecular Weight:570.115
Hs Code.:

Synonyms:10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

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Chemical Property of 10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

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Technology Process of 10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

There total 1 articles about 10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1387627-09-9
1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol

: 100-39-0
benzyl bromide

: 1442371-78-9
10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

Guidance literature:: 1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.034

Reference yield: 99.0%

: 109-01-3
1-methyl-piperazine

: 1442371-78-9
10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

: 1442371-81-4
10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-(4-methylpiperazin-1-yl)-10H-phenothiazine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In toluene; at 100 - 110 ℃; for 18h; Inert atmosphere; Alkaline conditions;
DOI:10.1016/j.bmc.2013.04.034

Reference yield: 80.0%

: 123-75-1
pyrrolidine

: 1442371-78-9
10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-chloro-10H-phenothiazine

: 1442371-82-5
10-{2-(benzyloxy)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-2-pyrrolidin-1-yl-10H-phenothiazine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In toluene; at 100 - 110 ℃; for 1.5h; Inert atmosphere; Alkaline conditions;
DOI:10.1016/j.bmc.2013.04.034